Uricosuric effect of dandelion root extract on oxonate-induced hyperuricemia in rats

This research aimed to investigate the uricosuric effect of dandelion plant extracts in hyperuricemic rats induced by potassium oxonate (PO).
 Methods. Hyperuricemia was using PO, and root were administered observe their impact on uric acid (UA) levels. The study involved adult male Swiss weighing approximately 150–180 grams, randomly divided into five groups (n = 6). Group 1 served as normal control group with no treatment. 2 received PO only. 3 oral administration 50 mg/kg extract 0.5 ml distilled water (DW) daily. 4 orally 100 powder DW 5 treated allopurinol.
 After 12 days, euthanized chloroform inhalation, sera collected directly from heart for biochemical analysis serum UA, urinary (UUA), well other liver renal parameters.
 Results. revealed that solution experienced a significant decrease blood UA levels increase UUA Dandelion treatment also influenced xanthine oxidase activity, differences observed kidney functions.
 Conclusion. Based findings this study, it can be concluded significantly reduces through activity demonstrates XO inhibitory effects.